Tamsulosin: α1-Adrenoceptor Subtype-Selectivity and Comparison With Terazosin
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چکیده
منابع مشابه
Yohimbine Dimers Exhibiting Selectivity for the Human 2c-Adrenoceptor Subtype
Yohimbine is a potent and selective 2versus 1-adrenoceptor antagonist. To date, drugs with high specificity for the 2-adrenoceptor show marginal selectivity among the three 2-adrenoceptor subtypes. Initial studies showed that yohimbine was about 4and 15-fold more selective for the human 2C-adrenoceptor in comparison with the 2Aand 2B-adrenoceptors, respectively. To improve on this 2-adrenocepto...
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We determined the binding affinity of tamsulosin, a selective α(1)-adrenoceptor antagonist, for human α(1)-adrenoceptor subtypes in comparison with those of other α(1)-adrenoceptor antagonists including silodosin, prazosin, 5-methylurapidil, terazosin, alfuzosin, nafopidil, urapidil and BMY7378. The association and dissociation kinetics of [(3)H]tamsulosin for recombinant human α(1)-adrenocepto...
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Alpha1a-adrenergic receptor (AR) primarily mediates the contraction of the prostatic and cavernous smooth muscles. Among clinically available alpha1-AR antagonists for the medical management of benign prostatic hyperplasia (BPH), tamsulosin has a modest selectivity for alpha1A- and alpha1D- over alpha1B-ARs. To compare the effects of various alpha1-AR antagonists on relaxation responses of cave...
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The effectiveness and safety of tamsulosin and terazosin for patients with benign prostatic hyperplasia (BPH) was evaluated by literature review. PubMed, Embase, the Cochrane Library, Chinese biomedicine literature database (CBM), reference lists of reports, and reviews were searched for randomized controlled trials (RCTs), or quasi-RCTs of tamsulosin versus terazosin in BPH. Twelve studies inv...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1998
ISSN: 0021-5198
DOI: 10.1254/jjp.78.331